Mental breakdowns transform ordinary people into ravenous monsters, and the space around them into dangerous areas called Biomes. Some get a hold of themselves and revert to their human forms, now with the ability to harness their new powers. These people are referred to as Shifters. Biome follows Eli, a shifter gang member, who after being caught by a Biome Extermination company must work for them to avoid the death penalty. He answers complex moral questions when he interacts with varying world views, striving to become a better person.

There is a phenomenon in which some people who have mental breakdowns transform themselves into ravenous monsters called hosts, and the world around them into dangerous areas called Biomes. Eli, a Biome Exterminator, is tasked with killing an ice golem to exterminate a biome on a cargo ship. Will this mission prove to be too difficult for Eli, or will he come out on top?

The Twins, The Bear and The Monster find themselves in The Stasis Hotel fighting over a briefcase with valuable information.

In a world full of inhuman creatures, superhumans, and gangs, Kenichi finds himself stuck after killing the brother of a rival gang leader. And after all the wrong choices, ends up knee-deep in the coorporate underworld of assassins. Follow Kenichi and his friends as he navigates a world full of dysfunction and oppression in a life changing journey for revenge.