The Uzi prototype was finished in 1950. It was first introduced to Israel Defense Forces (IDF) special forces in 1954, and the weapon was placed into general issue two years later. The IDF supplied Uzis to rear-echelon troops, officers, artillery troops and tank crews, as well as a frontline weapon by elite light infantry assault forces.

The Uzi has been exported to over 90 countries. Over its service lifetime, it has been manufactured by Israel Military Industries, FN Herstal, and other manufacturers. From the 1960s through to the 1980s, more Uzi submachine guns were sold to more military, law enforcement and security markets than any other submachine gun ever made.